A fluorescent conjugated polymer-based ratiometric aptasensor for highly specific and robust detection of perfluorooctanoic acid

Chemical Communications 2026 Open access

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Authors: Hao Liu, Qinfeng Xu, Zhao-zhao Zhang, Yanni Li, Chun-Yang Zhang
DOI: 10.1039/d5cc07080e
Cited by: 1
References: 42

Abstract

We develop a fluorescent conjugated polymer-based ratiometric aptasensor for highly specific and robust detection of perfluorooctanoic acid (PFOA). The presence of PFOA can induce aptamer folding and consequently the enhancement of the fluorescence resonance energy transfer (FRET) efficiency, facilitating the ratiometric detection of PFOA with a detection limit of 27 nM and excellent selectivity. This robust aptasensor can discriminate PFOA from common anionic surfactants, which remains a challenge for conjugated polymer-based PFOA sensors, and visually measures PFOA in complex aqueous samples.

Fields of Study & Subjects

Per- and polyfluoroalkyl substances research Molecular Sensors and Ion Detection Luminescence and Fluorescent Materials

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
11
Pages
3531–3535
Publication date
1 January 2026
Language
EN