Lewis acid-switched regiodivergent N 1 / N 2 -alkylation of ben-zotriazoles with α-hydroxyl diazo compounds

Chemical Communications 2026

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Authors: Jingjing Jiang, Jinghan Zhang, Nan Huang, H. Eric Xu, X. Liu, Jiayin Li, Xinlong Zhou, Jingjing Zhao, Pan Li
DOI: 10.1039/d5cc07167d
Cited by: 3
References: 43

Abstract

A Lewis acid-switching strategy that enables programmable selectivity between kinetically controlled N 1 -alkylation and thermodynamically favored N 2 -alkylation using β-hydroxy-α-diazo carbonyls as versatile electrophiles has been disclosed.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
10
Pages
3279–3282
Publication date
1 January 2026
Language
EN