Metal and additive-free synthesis of 2,4-disubstituted oxazoles via thiourea-mediated cyclization reaction

Chemical Communications 2026

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Authors: Huifeng Wang, Wenjing Ma, Lei Deng, Genting Huang, Sisi Gong, Xiuling Chen, Shi-Yong Liu
DOI: 10.1039/d5cc07183f
Cited by: 0
References: 32

Abstract

A novel, additive-free method has been developed for the synthesis of 2,4-disubstituted oxazoles through thiourea-mediated cyclization of substituted 2-oxo-2-phenylethyl acetates. This approach employs readily accessible thiourea and α-acyloxy ketones under mild conditions with straightforward operation, providing a reliable and versatile route to diverse substituted oxazoles.

Fields of Study & Subjects

Synthesis and Reactions of Organic Compounds Synthesis of heterocyclic compounds Structural and Chemical Analysis of Organic and Inorganic Compounds

Publication details

Journal / source
Chemical Communications
Volume
62
Issue
14
Pages
4342–4345
Publication date
1 January 2026
Language
EN