Rational design of a ruthenium–cupin complex as an artificial ketone reductase

Chemical Communications 2026 Open access

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Authors: Koki Matsumoto, Souto Kitazawa, Ryusei Matsumoto, Yoshitsugu Morita, Nobutaka Fujieda
DOI: 10.1039/d5cc07188g
Cited by: 3
References: 31

Abstract

-cymene)-cupin complex functioning as an artificial ketone reductase was developed through structure-guided engineering. Refinement of the primary and secondary coordination spheres based on a 1-His metal-binding motif enabled efficient asymmetric transfer hydrogenation of trifluoroacetophenone in water, affording up to 95% ee and 92% coupling efficiency.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Organometallic Complex Synthesis and Catalysis Metal-Catalyzed Oxygenation Mechanisms

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
21
Pages
5942–5946
Publication date
1 January 2026
Language
EN