A concise synthesis of indole-fused azepino- and azocino-indoles via acid-catalyzed 1,2-migration

Chemical Communications 2026

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Authors: Nabin Parui, Kousik Maji, Manab Diasi, Jyotirmayee Dash
DOI: 10.1039/d5cc07212c
Cited by: 3
References: 54

Abstract

]indoles from isatin derivatives is described. The modular sequence combines allyl-metal addition, Grignard-mediated 1,2-allyl migration, ring-closing metathesis, and an acid-catalyzed 1,2-aryl/alkyl migration-aromatization to afford tricyclic frameworks in good to excellent yields under mild conditions.

Fields of Study & Subjects

Synthesis and pharmacology of benzodiazepine derivatives Catalytic C–H Functionalization Methods Synthesis and bioactivity of alkaloids

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
25
Pages
6746–6750
Publication date
1 January 2026
Language
EN