A lipid droplet-targeted Pt( ii ) complex enables photoinduced ferroptosis and apoptosis against cisplatin-resistant cells

Chemical Communications 2026

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Authors: Puzhen Hui, Fengwu Xu, Huilin Zheng, Shankun Yao, Yuncong Chen, Xiaoxia Gu, Zijian Guo
DOI: 10.1039/d5cc07220d
Cited by: 4
References: 38

Abstract

lipid droplet (LD)-mediated pathways remains challenging. Herein, an LD-specific targeting Pt(II) complex was designed to address this limitation by directly inducing sufficient lipid peroxidation (LPO) accumulation, offering a novel platform for synergistic ferroptosis-apoptosis cancer therapy. This work provides a novel anticancer platform using photoactivated platinum complexes to concurrently trigger dual cell death pathways.

Fields of Study & Subjects

Cancer Lipids and Metabolism Ferrocene Chemistry and Applications Metal complexes synthesis and properties

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
21
Pages
5919–5923
Publication date
1 January 2026
Language
EN