Pd-catalyzed synthesis of deuterated olefins from (hetero)arenes and ketones via a cross-coupling approach

Chemical Communications 2026

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Authors: Happy Sharma, Bhoomika Duklan, Pokhriyal Yamini, Dongari Yadagiri
DOI: 10.1039/d5cc07257c
Cited by: 3
References: 47

Abstract

Here, we have developed a novel, straightforward approach for the synthesis of deuterium olefins from arenes, heteroarenes, and ketones, with broad substrate scope, high yields, and excellent deuterium incorporation. The practical applications of this methodology, as demonstrated through the synthesis of deuterium-containing active pharmaceutical drugs such as bexarotene, isocombretastatin-4 (IsoCA-4), and CC-5079, aim to show its relevance and potential impact in the pharmaceutical industry.

Fields of Study & Subjects

Chemical Reactions and Isotopes Catalytic C–H Functionalization Methods Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
18
Pages
5321–5325
Publication date
1 January 2026
Language
EN