Dual inhibition of ERα/NF-κB pathways coupled with sonodynamic therapy via a multifunctional AIEgen

Chemical Communications 2026

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Authors: Longli Hu, Zhi Zhang, Zhongyu Wang, Luolong Qing, Yuanli Yang, Xing Lu, Qiying Yu, Huan He, Silong Zhang
DOI: 10.1039/d5cc07274c
Cited by: 1
References: 23

Abstract

Here we report TBEP, a trifunctional sonosensitizer integrating aggregation-induced emission characteristics for ultrasound-triggered reactive oxygen species generation, estradiol-mediated ERα targeting, and pterostilbene-derived inflamation inhibition. This modular platform synergizes spatially precise SDT with tumor microenvironment modulation, offering a promising strategy for breast cancer therapy.

Fields of Study & Subjects

Ultrasound and Hyperthermia Applications Ultrasound and Cavitation Phenomena S100 Proteins and Annexins

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
16
Pages
4783–4786
Publication date
1 January 2026
Language
EN