Asymmetric synthesis of propargylic alcohols using bifunctional glucose dehydrogenases

Chemical Communications 2026 Open access

Read full text
Authors: Rohit Kumar, Simran Bhatia, Samantha J. Tambrini, Guangde Jiang
DOI: 10.1039/d5cc07322g
Cited by: 1
References: 37

Abstract

Two bifunctional glucose dehydrogenases enable asymmetric reduction of propargylic ketones, affording chiral propargylic alcohols in excellent yields, with gram-scale feasibility.

Fields of Study & Subjects

Enzyme Catalysis and Immobilization Cyclopropane Reaction Mechanisms Synthetic Organic Chemistry Methods

Publication details

Journal / source
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Volume
62
Issue
31
Pages
8042–8045
Publication date
1 January 2026
Language
EN