Triazole-stapled p53 mimetics as MDM2 inhibitors: structural and thermodynamic origin of enhanced binding affinity

Physical Chemistry Chemical Physics 2026

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Authors: Vikram Gaikwad, Pushyaraga P. Venugopal, Rajarshi Chakrabarti
DOI: 10.1039/d5cp03813h
Cited by: 2
References: 68

Abstract

Triazole-stapled p53 peptides effectively block the oncogenic p53–MDM2 interaction by strengthening peptide–protein contacts and water-mediated interactions. Stapling at positions 4–11 enhances the binding affinity of p53 towards MDM2.

Fields of Study & Subjects

Cancer-related Molecular Pathways Click Chemistry and Applications Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
Physical Chemistry Chemical Physics
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
10
Pages
6353–6364
Publication date
1 January 2026
Language
EN