Sweet optimization: glucose-vitrified samples for hyperpolarizing glutamine in biological studies

Physical Chemistry Chemical Physics 2026 Open access

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Authors: Lea Gutierrez, Karen Dos Santos, Mehdi Soussi-Thérond, Aiky Razanahoera, Daniel Abergel, Nicolas Giraud, Mathieu Baudin
DOI: 10.1039/d5cp03827h
Cited by: 0
References: 22

Abstract

This work describes the development of a versatile formulation using glucose as a vitrification agent in dynamic nuclear polarization. Significantly high polarization levels are achieved through optimization of a sample formulation, using sodium acetate and glutamine as targets. The best optimized formulation allowed precise monitoring of the enzymatic conversion of glutamine to glutamate, paving the way for advances in cellular metabolism applications.

Fields of Study & Subjects

Advanced NMR Techniques and Applications Nonlinear Optical Materials Research Solid-state spectroscopy and crystallography

Publication details

Journal / source
Physical Chemistry Chemical Physics
Volume
28
Issue
2
Pages
1094–1099
Publication date
1 January 2026
Language
EN