A Zundel ion in the catalytic proton transfer pathway of [FeFe]-hydrogenase

Physical Chemistry Chemical Physics 2026 Open access

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Authors: Lingling Liu, Max A. Klamke, Federica Arrigoni, Oliver Lampret, Julian T. Kleinhaus, Ulf-Peter Apfel, Eckhard Hofmann, Claudio Greco, Thomas Happe, Sven T. Stripp, Jifu Duan
DOI: 10.1039/d5cp04267d
Cited by: 4
References: 53

Abstract

[FeFe]-hydrogenases catalyze the interconversion of protons, electrons, and hydrogen. New findings suggest the presence of a Zundel ion in the proton transfer pathway that influences the active site cofactor via the vibrational Stark effect.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Metal-Catalyzed Oxygenation Mechanisms Organometallic Complex Synthesis and Catalysis

Publication details

Journal / source
Physical Chemistry Chemical Physics
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
11
Pages
7101–7110
Publication date
1 January 2026
Language
EN