Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules

Chemical Society Reviews 2026

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Authors: Guilherme Fernandes, Seong‐Heun Kim, Jean Leandro dos Santos, Yuhang Wang, Christelle Soudy, Joanna M. Redmond, Daniele Castagnolo, Matthew H. Todd
DOI: 10.1039/d5cs00617a
Cited by: 1
References: 503

Abstract

antibacterial efficacy. We also provide an outline of the current clinical pipeline, highlighting areas of innovation and remaining gaps. Our goal is to offer a comprehensive perspective on antibacterial discovery that supports ongoing efforts to strengthen the pipeline in response to antimicrobial resistance.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Cancer therapeutics and mechanisms Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
Chemical Society Reviews
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
14
Pages
7853–7932
Publication date
1 January 2026
Language
EN