Bridging the gap: gradient scaffolds as bioinstructive platforms for peripheral nerve repair

Chemical Society Reviews 2026

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Authors: Jie Gao, Feng Xiong, Zhichao Yang, Xilin Ye, Ke Ma, Biyin Shi, Zhisheng Li, Kaixin Long, Zhengwei You, Liqun Zhang, Huiyu Liu, Jie Xue
DOI: 10.1039/d5cs00738k
Cited by: 4
References: 122

Abstract

regenerative outcomes, highlighting how chemically engineered gradients synergize with structural guidance to promote organized nerve regeneration. Finally, we outline key challenges, including gradient stability, reproducibility, and compatibility with scalable manufacturing, and discuss future directions for the clinical translation of gradient-based NGCs.

Fields of Study & Subjects

Nerve injury and regeneration Graphene and Nanomaterials Applications Silk-based biomaterials and applications

Publication details

Journal / source
Chemical Society Reviews
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
8
Pages
4376–4408
Publication date
1 January 2026
Language
EN