Multifaceted maleimide scaffolds in focus: from synthesis to photophysical applications

mono- or dihalogenation of maleic anhydride, these approaches offer limited structural diversity and often require multiple steps. In this work, we highlight recent developments in non-conventional synthetic strategies for accessing 3- and 3,4-substituted maleimides. Special emphasis is placed on methodologies based on transition metal catalysis and organocatalysis, which enable the direct introduction of substituents onto the maleimide core. These advances expand the diversity of accessible structures, facilitating new applications and reactivity profiles. In selected cases, we also discuss how these synthetic routes have led to the development of maleimide derivatives with notable photophysical properties, particularly fluorescence, which may serve in future applications. Overall, this tutorial review provides a comprehensive synthetic perspective on recent advances in the field, aiming to support further innovation in maleimide chemistry.