The sustainability of the Morita–Baylis–Hillman reaction

Chemical Society Reviews 2026

View at publisher
Authors: Thaynan A B Chagas, Manoel Trindade Rodrigues Junior, Fábio S. Fernandes, Luna S Dos Santos, Cíntia D F Milagre, Wanda P. Almeida, Fernando Coelho
DOI: 10.1039/d5cs01408e
Cited by: 1
References: 187

Abstract

The Morita-Baylis-Hillman reaction is a chemical transformation that yields highly versatile polyfunctionalized products. These products serve as valuable substrates for developing new synthetic methodologies, synthesizing various natural products, and creating molecules with diverse biological activities. This reaction fulfils several criteria for classifying a transformation as "green". In this review, we provide a critical assessment of all the sustainability aspects of this reaction and their application in a wide range of synthetic preparations. We examine the reaction conditions-including solvents and catalysts-as well as innovative strategies that position the Morita-Baylis-Hillman reaction as a sustainable transformation.

Fields of Study & Subjects

Synthesis of heterocyclic compounds Asymmetric Synthesis and Catalysis Synthesis and Reactions of Organic Compounds

Publication details

Journal / source
Chemical Society Reviews
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
11
Pages
6155–6181
Publication date
1 January 2026
Language
EN