Mechanistic insights into double-bond migration mediated by bifunctional dehydratases in ansamitocin biosynthesis

Catalysis Science & Technology 2026

View at publisher
Authors: Yingzhe Guo, Jiaxi Guo, Zeqian Du, Ting Shi
DOI: 10.1039/d5cy01366f
Cited by: 0
References: 41

Abstract

Ansamitocin, a potent antitumor polyketide compound from Actinosynnema pretiosum , is assembled by a modular type I polyketide synthase (PKS-I).

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis biodegradable polymer synthesis and properties Bioactive Natural Diterpenoids Research

Publication details

Journal / source
Catalysis Science & Technology
Volume
16
Issue
6
Pages
1951–1961
Publication date
1 January 2026
Language
EN