Light- and copper-activated (photo)cytotoxicity of 8-hydroxyquinoline-based boron photosensitizers with lipid droplet targeting and lipid peroxidation accumulation

Dalton Transactions 2026 Open access

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Authors: Thanh Chung Pham, Gun Kim, Pham Van Thong, Tran Ngoc Dung, Hung Tan Pham, Nguyen Van Trang, Lê Thị Hồng Hải, Arne Meulemans, Luc Van Meervelt, Eduard Fron, Mark Van der Auweraer, Daniel Escudero
+2 more Hue Minh Thi Nguyen, Wim Dehaen
DOI: 10.1039/d5dt01016k
Cited by: 2
References: 44

Abstract

ions, and the produced complexes enhance cytotoxicity instead. The photophysical properties of the complexes were comprehensively studied by a combination of experimental measurements, quantum mechanical (QM) and hybrid QM/molecular mechanics (MM) simulations. Thus, this investigation offers insights into new molecular design approaches for multifunctional probes with potential applications in photodynamic therapy and chemotherapy for cancer treatment.

Fields of Study & Subjects

Luminescence and Fluorescent Materials Organoboron and organosilicon chemistry Photochromic and Fluorescence Chemistry

Publication details

Journal / source
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
4
Pages
1844–1854
Publication date
1 January 2026
Language
EN