Naphthoquinone-derived tridentate Ru( ii ) and Os( ii ) organometallics with exceptional cytotoxicity: synthesis, characterization, stability in aqueous solution and biological in vitro evaluation

Dalton Transactions 2026 Open access

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Authors: Alexander Rosner, Heiko Geisler, Michaela Hejl, Mathias Gradl, Anton A. Legin, Alexander Roller, Michael A. Jakupec, Petra Heffeter, Walter Berger, Bernhard K. Keppler, Wolfgang Kandioller
DOI: 10.1039/d5dt01649e
Cited by: 0
References: 51

Abstract

cytotoxicity; however, longer and branched substituents did not improve the cellular accumulation. Cell cycle experiments showed consistent cell cycle inhibition in both SW480 and CH1/PA-1 cells for ruthenium-based compounds only. Indolamin-2,3-dioxygenase 1 (IDO1) inhibition assays in SKOV3 cells revealed significant inhibitory potential of Ru-Ethyl, in clear distinction to other ruthenium and osmium complexes.

Fields of Study & Subjects

Metal complexes synthesis and properties Bioactive Compounds and Antitumor Agents Organometallic Complex Synthesis and Catalysis

Publication details

Journal / source
Dalton Transactions
Volume
55
Issue
5
Pages
2254–2268
Publication date
1 January 2026
Language
EN