Rational engineering of a Schiff base–iridium( iii ) complex for enhanced photodynamic therapy

Dalton Transactions 2026

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Authors: Changlin Li, Xuan Liu, Tao Shao, Guodang Chen, Jingran Xuan, D. Wang, Zhenbao Li, Zhihui Feng
DOI: 10.1039/d5dt02158h
Cited by: 1
References: 31

Abstract

studies confirm its potent cytotoxicity against HepG2 cells. In a 4T1 tumor-bearing mouse model, Ir-NCN-mediated PDT exhibited superior therapeutic efficacy compared to the cisplatin control group, with no significant toxicity observed. This study provides new insights into the development of highly efficient and low-toxicity PDT agents, demonstrating promising potential for clinical translation.

Fields of Study & Subjects

Photodynamic Therapy Research Studies Metal complexes synthesis and properties Nanoplatforms for cancer theranostics

Publication details

Journal / source
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
6
Pages
2533–2541
Publication date
1 January 2026
Language
EN