Silver( i ) coordination polymer meets chia seed mucilage based film – antimicrobial performance and evaluation of permeability trends through human skin in vitro

Dalton Transactions 2026

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Authors: Sabina W. Jaros, Justyna Markieton, Magdalena Florek, Jarosław Król, Seeprarani Rath, Sesha Rajeswari Talluri, Nubul Albayati, Bożena Michniak-Kohn
DOI: 10.1039/d5dt02494c
Cited by: 2
References: 32

Abstract

drug permeation analysis of 1 using human cadaver skin as a membrane revealed the potential for topical delivery of antimicrobial compound 1 for localized action in the upper layers of the epidermis, specifically the stratum corneum, and the transdermal delivery of diclofenac sodium (a nonsteroidal anti-inflammatory drug, NSAID). This development not only opens the door to the exploration of Ag(I)-based coordination polymers as promising transdermal drug delivery systems, but it also significantly enhances the narrow field of therapeutic coordination polymers that exhibit synergistic effects of antimicrobial, anti-inflammatory, and demulcent action.

Fields of Study & Subjects

Hydrogels: synthesis properties applications Wound Healing and Treatments Polysaccharides Composition and Applications

Publication details

Journal / source
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
6
Pages
2443–2451
Publication date
1 January 2026
Language
EN