From polyamines to nanogels: a supramolecular approach for boosting relaxivity of [Gd(DOTP)] 5−
Abstract
solutions with increasing amounts of the cationic substrates allow determination of the ion-pair binding constants as well as the relaxivity of the resulting supramolecular adducts. The strength of these interactions increases with the number of positive charges on the polyamine and depends strongly on pH, reflecting the optimal balance of charges between anion and cation. A further and remarkable enhancement in relaxivity is observed when the metal complex is confined within nanogels. Analysis of the corresponding NMRD (Nuclear Magnetic Relaxation Dispersion) profiles highlights the essential contribution of well-organized second-sphere water molecules with restricted mobility, which are responsible for the unusually high relaxivity values at magnetic fields relevant for MRI.
Fields of Study & Subjects
Lanthanide and Transition Metal Complexes
Supramolecular Chemistry and Complexes
Metal-Organic Frameworks: Synthesis and Applications
Publication details
- Journal / source
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 55
- Issue
- 4
- Pages
- 1727–1738
- Publication date
- 1 January 2026
- Language
- EN