In medio stat virtus : asymmetric Salphen metal complexes with improved biological properties

Dalton Transactions 2026

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Authors: Luisa D'Anna, Aurane Froux, Riccardo Bonsignore, Alexander Roller, Christian R. Kowol, Antonio Andrea Monari, Stéphanie Grandemange, Giampaolo Barone, Alessio Terenzi
DOI: 10.1039/d5dt02881g
Cited by: 2
References: 35

Abstract

passive transport, and fluorescence microscopy revealed cytoplasmic accumulation. Notably, the asymmetric complex significantly reduced cancer cell viability, inhibited proliferation, and induced apoptotic cell death, as evidenced by PARP cleavage. These findings underscore the potential of asymmetric Salphen complexes as promising anticancer agents and provide valuable insights for the rational design of metal-based therapeutics based on the Salphen scaffold.

Fields of Study & Subjects

Synthesis and characterization of novel inorganic/organometallic compounds Metal complexes synthesis and properties Crystal structures of chemical compounds

Publication details

Journal / source
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Volume
55
Issue
10
Pages
4250–4258
Publication date
1 January 2026
Language
EN