NIR-responsive upconversion nanoplatforms: an anionic drug carrier for ROS amplification induced by β-amyloid fibrils
Abstract
that positively correlated with CH modification levels. Under NIR irradiation, the nanoplatform triggered a photodynamic effect with abundant ROS. Notably, compared with the control group and Aβ monomer group, the ROS generation in the Aβ fibril group was approximately doubled, which further enhanced the targeted therapeutic efficacy of the system. By integrating NIR responsiveness, cationic chitosan, targeted ROS generation, and low systemic toxicity, the nanoplatform provides a novel strategy for the photooxidative treatment of AD and offers insights into the design of chitosan-modified upconversion nanoparticle-based drug carrier systems.
Fields of Study & Subjects
Polyoxometalates: Synthesis and Applications
Advanced Nanomaterials in Catalysis
Alzheimer's disease research and treatments
Publication details
- Journal / source
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 55
- Issue
- 9
- Pages
- 3709–3722
- Publication date
- 1 January 2026
- Language
- EN