Caenorhabditis elegans fed native gut microbiota have altered bioenergetic pathway utilization impacting mitochondrial function and susceptibility to pollutants

Environmental Science Processes & Impacts 2026 Open access

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Authors: Christina M. Bergemann, Laura E. Jameson, Isabel W. Kenny-Ganzert, Javier Huayta, Pol Castellano‐Escuder, Arunabh Sarkar, Olga Ilkayeva, David R. Sherwood, Matthew D. Hirschey, Joel N. Meyer
DOI: 10.1039/d5em00624d
Cited by: 0
References: 68

Abstract

grown on BIGb0170 had lower amounts of triglycerides and acylcarnitines. ATP levels were partially rescued by supplementing BIGb0170 with pyruvate. This work suggests that BIGb0170 can impact mitochondrial function through changes in metabolite abundance, which can increase sensitivity to the Complex I inhibitor rotenone.

Fields of Study & Subjects

Gut microbiota and health Environmental Toxicology and Ecotoxicology Genetics Aging and Longevity in Model Organisms

Publication details

Journal / source
Environmental Science Processes & Impacts
Volume
28
Issue
5
Pages
1309–1322
Publication date
1 January 2026
Language
EN