Proteins and lunasin from Glycine soja inhibited inflammation by activating the Hippo pathway through phosphorylation of YAP1 kinase

Food & Function 2026 Open access

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Authors: Jennifer Kusumah, Jiazheng Yuan, Elvira González de Mejı́a
DOI: 10.1039/d5fo02971f
Cited by: 1
References: 78

Abstract

proteins and peptides inhibited inflammation by decreasing pro-inflammatory cytokines IL-6, IL-1β, and MCP-1, phosphorylating YAP1 and LATS1/2, and increasing YAP1 cytoplasmic retention, thus activating the Hippo pathway. The results suggest that soybean proteins and peptides inhibited inflammation through the Hippo pathway, offering novel developments of functional food ingredients or supplements for a healthier diet.

Fields of Study & Subjects

Hippo pathway signaling and YAP/TAZ Proteoglycans and glycosaminoglycans research Polysaccharides and Plant Cell Walls

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1531–1549
Publication date
1 January 2026
Language
EN