Epigenetic regulation by oleacein mitigates IL-1β-induced inflammation in human SW982 synovial cells

Food & Function 2026 Open access

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Authors: Rocío Muñoz-García, María Paredes-Sánchez, C. Alarcón-de-la-Lastra, Mari Cruz Sánchez-Hidalgo
DOI: 10.1039/d5fo03172a
Cited by: 1
References: 79

Abstract

) and regulated IL-1β-induced changes in DNA methylation modulating DNMT1 and DNMT3 gene expression and global DNA methylation. These results show OLA as a promising epigenetic regulator of the inflammatory response in rheumatic diseases.

Fields of Study & Subjects

Inflammasome and immune disorders Fatty Acid Research and Health Sphingolipid Metabolism and Signaling

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
1970–1983
Publication date
1 January 2026
Language
EN