Linking intestinal bitter taste receptors and GSPE-induced long-lasting benefits in ageing rats: an integrative analysis

Food & Function 2026 Open access

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Authors: Adrià Vilalta, Maria Descamps-Solà, Marta Sierra-Cruz, Alba Miguéns-Gómez, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Montserrat Pinent, Maria Teresa Blay, Anna Ardèvol, Ximena Terra
DOI: 10.1039/d5fo03241e
Cited by: 1
References: 50

Abstract

secretion, intestinal barrier dysfunction indices, some microbiota genera and several Tas2r transcripts among the 34 strongest discriminators. Tas2rs formed high-betweenness hubs linking epithelial integrity, inflammatory tone and butyrate-producing taxa. These findings indicate that intestinal type-2 bitter taste receptors (Tas2rs) may integrate multisystem regulatory networks fundamental to healthy ageing. Brief administration of grape-seed proanthocyanidin extract (GSPE) is sufficient to durably reprogramme Tas2r expression and the surrounding microbiota-endocrine-barrier landscape in aged rats.

Fields of Study & Subjects

Biochemical Analysis and Sensing Techniques Olfactory and Sensory Function Studies Advanced Chemical Sensor Technologies

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1336–1349
Publication date
1 January 2026
Language
EN