From wild plant to functional ingredient: phytochemical insights and neuroprotective activity of Melissa officinalis subsp. altissima

Food & Function 2026 Open access

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Authors: Donatella Ambroselli, Fabrizio Masciulli, Manal El Ali, Annalisa Chiavaroli, Claudio Ferrante, Simonetta Cristina Di Simone, Cinzia Ingallina, Luisa Mannina, Alain Muselli
DOI: 10.1039/d5fo04584c
Cited by: 0
References: 92

Abstract

murine assays. Notably, the extracts modulated the gene expression of key mediators such as TNF-α, NOS-2, IL-6, BDNF, and AChE suggesting a potential role in supporting brain health. These findings reinforce the potential of this lemon balm subspecies as a valuable natural ingredient for the formulation of functional foods and nutraceuticals with antioxidant, neuroprotective, and preservative properties. Moreover, the study underscores the broader significance of native aromatic plants as sustainable resources for health-oriented food innovation.

Fields of Study & Subjects

Medicinal Plants and Neuroprotection Medicinal Plant Extracts Effects Phytochemicals and Antioxidant Activities

Publication details

Journal / source
Food & Function
Volume
17
Issue
5
Pages
2206–2224
Publication date
1 January 2026
Language
EN