Rutin alleviates dietary advanced glycation end products (AGEs)-induced insulin resistance in mice by modulation of gut microbiota

Food & Function 2026

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Authors: Yi Lu, Lijun Chang, Shuangbo Liu, Mingfu Wang, Yueliang Zhao
DOI: 10.1039/d5fo04604a
Cited by: 2
References: 43

Abstract

. Concurrently, rutin increased fecal concentrations of short-chain fatty acids (SCFAs), notably acetic acid and propionic acid. Spearman's correlation analysis confirmed negative associations between rutin-modulated microbiota and IR indicators. These results demonstrate that rutin mitigates AGEs-induced IR by reshaping the gut microbiome and promoting beneficial microbial metabolites.

Fields of Study & Subjects

Advanced Glycation End Products research Genomics phytochemicals and oxidative stress Antioxidants Aging Portulaca oleracea

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1451–1464
Publication date
1 January 2026
Language
EN