Chlorogenic acid alleviates chronic restraint stress-induced liver injury potentially via Nrf2-mediated inhibition of ferroptosis and mitochondrial apoptosis

Food & Function 2026

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Authors: Haoyang Tan, Yaxin Ji, X. Jiang W. Cheng, Jiahuan Hu, Xiaoqing Yu, Jiaxing Wang, Haotian Yang, Shuai Zhang, Guofeng Feng, Wenjing Jiao, Yuan Zhao, Honggang Fan
DOI: 10.1039/d5fo04627k
Cited by: 3
References: 29

Abstract

activation of the Nrf2 signaling pathway. These hepatoprotective effects were abolished by the Nrf2 inhibitor brusatol, highlighting the central role of Nrf2 in mediating CGA's antioxidant and cytoprotective actions. This study reveals a novel therapeutic strategy targeting the Nrf2 axis to mitigate oxidative stress and ferroptosis-related liver injury under chronic stress.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Genomics phytochemicals and oxidative stress Selenium in Biological Systems

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
2
Pages
1061–1073
Publication date
1 January 2026
Language
EN