Sulfated polysaccharides from sea cucumber mitigate acetaminophen-induced acute liver injury in mice via citraconic acid-mediated inhibition of oxidative stress

Food & Function 2026

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Authors: Jiacheng Cheng, Weiyun Zheng, Jiayi Yan, Shuang Song, Chunqing Ai
DOI: 10.1039/d5fo04767f
Cited by: 3
References: 74

Abstract

Sea cucumber sulfated polysaccharides alleviate acetaminophen - induced liver injury by modulating gut microbiota to elevate citraconic acid, which activates hepatic Nrf2 to reduce oxidative stress, as validated in vivo and in t-BHP-treated cells.

Fields of Study & Subjects

Echinoderm biology and ecology Genomics phytochemicals and oxidative stress Seaweed-derived Bioactive Compounds

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
2
Pages
1074–1092
Publication date
1 January 2026
Language
EN