Early-life gut microbial reconstitution with Lactobacillus johnsonii during lactation mitigates high-fat diet-induced obesity in adult mice

Food & Function 2026

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Authors: Zhongxin Li, Zhifei Wang, Qiang Huang, Zhuqing Xie, Bin Zhang
DOI: 10.1039/d5fo04887g
Cited by: 0
References: 45

Abstract

during the lactation period substantially mitigated these programmed metabolic alterations. Our findings causally link ELOF, early-life gut microbial imbalance, and late-onset obesity in mice, and suggest that probiotic intervention during critical developmental periods may serve as an effective strategy to mitigate the obesity imprint in infants and young children.

Fields of Study & Subjects

Gut microbiota and health Infant Nutrition and Health Probiotics and Fermented Foods

Publication details

Journal / source
Food & Function
Volume
17
Issue
4
Pages
1783–1793
Publication date
1 January 2026
Language
EN