Sea cucumber sulfated fucan protects against acute liver injury in mice: insights from inflammatory responses, gut microbiota and hepatic metabolic profile analyses

Food & Function 2026

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Authors: Feifei Shi, Liting Zheng, Luoyu Wang, Bin Liu, Weiling Guo, Peng Liang
DOI: 10.1039/d5fo04947d
Cited by: 1
References: 47

Abstract

. Liver metabolomics analysis revealed that FUC reversed LPS-induced disturbances in purine metabolism, arachidonic acid metabolism, and tryptophan metabolism. This study demonstrates that sulfated fucan from sea cucumber exerts hepatoprotective effects by modulating the "gut-liver axis", providing a scientific basis for its use as a functional food or dietary supplement in the prevention of ALI.

Fields of Study & Subjects

Echinoderm biology and ecology Seaweed-derived Bioactive Compounds Immune Response and Inflammation

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
5
Pages
2586–2598
Publication date
1 January 2026
Language
EN