6-Gingerol ameliorates endothelial injury in hyperlipidemia mice via Nrf2 activation and inflammation modulation

Food & Function 2026

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Authors: Xu He, Yuepeng Shang, Xinyu Liao, Guanting Liu, Qingyao Yang, Jiaqi Liu, Xiaolong Xu, Xuyun Liu
DOI: 10.1039/d5fo05038c
Cited by: 4
References: 32

Abstract

the p38 MAPK-NF-κB signaling pathway. In summary, our study provides evidence that 6-gingerol ameliorates lipotoxicity-induced endothelial injury through coordinated modulation of the Erk-Nrf2 and p38-NF-κB signaling pathways, highlighting its potential as a novel preventive candidate for endothelial dysfunction in cardiovascular diseases.

Fields of Study & Subjects

Ginger and Zingiberaceae research Genomics phytochemicals and oxidative stress Immune cells in cancer

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
2
Pages
1007–1017
Publication date
1 January 2026
Language
EN