Momordicine I, a triterpene from bitter melon ( Momordica charantia L.), ameliorates alcohol-associated liver disease: research on the possible liver benefits

Food & Function 2026

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Authors: Yu Hou, Si-Ying Wang, Zi-Yi Xu, Guo Xin, Guiyun Zhao, Haiming Sun
DOI: 10.1039/d5fo05054e
Cited by: 1
References: 43

Abstract

, M-I intervention effectively improved liver steatosis, serum transaminase levels and mitochondrial function, while Nurr1 knockdown mice exhibited more severe ALD. In summary, M-I exerts liver-protective effects by targeting Nurr1, synergistically regulating lipid metabolism and mitochondrial function in hepatocytes, and inhibiting inflammatory responses. This study clarifies the new mechanism of M-I based on Nurr1, providing an important basis for its development as a therapeutic drug for ALD.

Fields of Study & Subjects

Natural Antidiabetic Agents Studies Psidium guajava Extracts and Applications Drug-Induced Hepatotoxicity and Protection

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
2018–2036
Publication date
1 January 2026
Language
EN