Citropten from Citrus sinensis peel protects against obstructive chronic kidney disease: insights from network pharmacology and experimental validation
Abstract
for 21 days) significantly preserved kidney function and histological architecture. CTP treatment also significantly attenuated extracellular matrix (ECM) accumulation and epithelial-mesenchymal transition (EMT), indicating reduced renal fibrosis. Mechanistic evaluation of hub targets demonstrated that CTP effectively modulated the Nrf2/NF-κB1/PARP1 signalling axis, a pivotal regulator of oxidative stress and inflammation. Consistent with pathway prediction, downstream validation revealed that CTP activated PINK1/Parkin/LC3B-mediated mitophagy, thereby restoring mitochondrial quality. Collectively, these findings suggest that CTP is a promising food-derived, multi-target bioactive candidate with potential therapeutic relevance for CKD management.
Fields of Study & Subjects
Chronic Kidney Disease and Diabetes
Heart Failure Treatment and Management
Chemotherapy-induced organ toxicity mitigation
Publication details
- Journal / source
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 6
- Pages
- 2687–2705
- Publication date
- 1 January 2026
- Language
- EN