Sea cucumber peptides alleviate hyperuricemic nephropathy via HIF-1α/NF-κB/STAT3-SIRT1/p300 axis-mediated metabolic and epigenetic modulation

Food & Function 2026

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Authors: Peiting Lv, Xinran Liu, Ximing Yang, Xue Sang, Lushun Yuan, Shuzhen Cheng, Ming Du
DOI: 10.1039/d5fo05202e
Cited by: 4
References: 61

Abstract

the SIRT1/p300 axis, suppressing global protein and histone lactylation. Concurrently, SCPs inhibited the HIF-1α/NF-κB/STAT3 pathway, decoupling metabolic-inflammatory signaling. These findings demonstrate that SCPs alleviate HN through multi-targeted regulation of urate metabolism, metabolic reprogramming, and lactylation, offering a novel strategy for functional food development.

Fields of Study & Subjects

Gout Hyperuricemia Uric Acid Seaweed-derived Bioactive Compounds Echinoderm biology and ecology

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
6
Pages
2907–2926
Publication date
1 January 2026
Language
EN