Cyanidin-3- O -glucoside promotes late-stage venous thrombus resolution in mice, accompanied by reduced macrophage M1-associated inflammation and attenuated HIF-1α-linked signaling

Food & Function 2026

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Authors: Yu-He Shen, Zhou-Yu Nie, Jia-Qi Zhang, Jia-Qi Xi, Meng-Jiao Lu, Yang Shen, Yong-Bing Cao, Li-Chao Zhang, Ling Li
DOI: 10.1039/d5fo05273d
Cited by: 1
References: 56

Abstract

-induced hypoxia-mimetic model, C3G reduced reactive oxygen species generation, restored antioxidant capacity, limited apoptosis and reduced markers of hypoxia and glycolysis regulated by HIF-1α. These findings indicate that C3G is associated with late-stage thrombus resolution in parallel with modulating macrophage polarization and HIF-1α-mediated metabolic adaptation, supporting further evaluation of this food-derived compound as a candidate adjunct for modulating the thrombus microenvironment.

Fields of Study & Subjects

Venous Thromboembolism Diagnosis and Management Liver Disease and Transplantation Phytochemicals and Antioxidant Activities

Publication details

Journal / source
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
6
Pages
2718–2735
Publication date
1 January 2026
Language
EN