Scalable mechanochemical synthesis of amides using bead milling technology

Green Chemistry 2026 Open access

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Authors: Pietro Caboni, Andrea Porcheddu, Sándor B. Ötvös, C. Oliver Kappe
DOI: 10.1039/d5gc04764a
Cited by: 14
References: 65

Abstract

A scalable protocol for mechanochemical amide bond formation was developed using a commercially available agitator bead mill without requiring reagent excess, added base or large quantities of organic solvent, significantly reducing waste generation.

Fields of Study & Subjects

Crystallography and molecular interactions Chemical Synthesis and Analysis Supramolecular Chemistry and Complexes

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
4
Pages
2049–2055
Publication date
1 January 2026
Language
EN