A bio-inspired environmentally friendly and cost-effective chemo-enzymatic synthesis of (−)-ambrox from trans -nerolidol

Green Chemistry 2026

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Authors: Jianlin Liu, Yi Zhang, Shaoping Zhang, Changle Zhao, Ganlu Zhang, Shengbin Zhou, Xiaoguang Yan, Weiguo Li, Qinggele Caiyin, J. Y. Qiao
DOI: 10.1039/d5gc05456g
Cited by: 2
References: 44

Abstract

An efficient chemo-enzymatic synthetic route of (−)-ambrox is established, leveraging the inexpensive starting material trans -nerolidol provided by de novo biosynthesis in Saccharomyces cerevisiae at a titre of 26.4 g L −1 .

Fields of Study & Subjects

Biochemical and biochemical processes Enzyme Catalysis and Immobilization Microbial Natural Products and Biosynthesis

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
12
Pages
5240–5258
Publication date
1 January 2026
Language
EN