Divergent synthesis of unique trifluoromethyl alcohols through Lewis acid-catalyzed anti-Meinwald rearrangement

Green Chemistry 2026

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Authors: Yu Zhang, Dinggang Wang, Lijun Zhang, Ziyang Qiu, Licheng Zhou, Miaomiao Zhuo, Le Zhang, Dong Lu, Xin Luan, Weidong Zhang
DOI: 10.1039/d5gc05493a
Cited by: 1
References: 68

Abstract

A metal-free, Lewis acid-catalyzed ring-opening of trifluoromethyl epoxides is reported. This divergent method facilitates gram-scale synthesis of pseudo-natural products and late-stage functionalization of drugs with potent antitumor activity.

Fields of Study & Subjects

Fluorine in Organic Chemistry Advanced Synthetic Organic Chemistry Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
8
Pages
3604–3613
Publication date
1 January 2026
Language
EN