Palladium-catalyzed asymmetric sequential hydroalkylation and hydroamination of 1,3-enynes with 3-hydroxyindoles

Green Chemistry 2026 Open access

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Authors: Qiuyu Li, Ruixue Wu, Tao Wu, Renkang Wei, Zhijiao Li, Shang Gao, Minyan Wang, Hequan Yao, Aijun Lin
DOI: 10.1039/d5gc05558j
Cited by: 3
References: 101

Abstract

An unprecedented Pd-catalyzed asymmetric sequential hydroalkylation/hydroamination of 1,3-enynes was developed. This method provides efficient access to chiral pyrido[1,2- a ]indoles and derivatives in good yields with excellent enantioselectivities.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
7
Pages
3232–3242
Publication date
1 January 2026
Language
EN