Substrate tunnel redesign of short-chain dehydrogenase enabled efficient biocatalytic production of the TRPV1 antagonist trans -4- tert -butylcyclohexanol

Green Chemistry 2026

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Authors: Ting Wang, Lidan Ye, Hongwei Yu
DOI: 10.1039/d5gc06523b
Cited by: 3
References: 46

Abstract

Redesign of the short-chain dehydrogenase UCPA via tunnel engineering for biocatalytic production of trans -4- tert -butylcyclohexanol with high activity and diastereoselectivity.

Fields of Study & Subjects

Enzyme Catalysis and Immobilization Microbial metabolism and enzyme function Microbial Metabolic Engineering and Bioproduction

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
9
Pages
4130–4142
Publication date
1 January 2026
Language
EN