Late-stage C–H amidation of pharmaceuticals enabled by earth-abundant Co( iii )-catalysis

Green Chemistry 2026 Open access

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Authors: Daniele Antermite, Elisa Y. Lai, João C. A. Oliveira, Stig D. Friis, Johan R. Johansson, Prof. Dr. Lutz Ackermann, Magnus J. Johansson
DOI: 10.1039/d5gc06524k
Cited by: 1
References: 42

Abstract

Cobalt-catalysis enables single-step late-stage C–H amidation of pharmaceuticals under mild, chemoselective conditions in a green solvent with broad functional group tolerance, reducing step counts and predicted PMI versus traditional strategies.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions Chemical Synthesis and Analysis

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
13
Pages
5613–5619
Publication date
1 January 2026
Language
EN