A combined microwave/continuous flow approach for the iodination of anilines and consecutive Mizoroki–Heck cross-coupling

Green Chemistry 2026 Open access

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Authors: Matteo Bartalucci, Filippo Bocerani, Francesco Ferlin, Luciano Lattuada, Fulvio Uggeri, Luigi Vaccaro
DOI: 10.1039/d5gc06815k
Cited by: 1
References: 62

Abstract

We report a modular, microwave-assisted continuous-flow approach for the selective iodination of unprotected anilines for API synthesis, achieving control of regioselectivity, and over-halogenation, avoiding the need for a protecting group.

Fields of Study & Subjects

Vanadium and Halogenation Chemistry Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Green Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
28
Issue
13
Pages
5701–5708
Publication date
1 January 2026
Language
EN