Modeling amyotrophic lateral sclerosis (ALS) in vitro : from mechanistic studies to translatable drug discovery

Lab on a Chip 2026

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Authors: Kathryn G. Maskell, Anthony L. Cook, Anna Elizabeth King, Tracey C. Dickson, C. Leigh Blizzard
DOI: 10.1039/d5lc00577a
Cited by: 0
References: 124

Abstract

ALS causes degeneration of the corticomotor system. Developing effective in vitro models of this complex disease requires careful selection of cell sources and thoughtful model design to achieve reliable experimental outcomes. Created with BioRender.

Fields of Study & Subjects

Amyotrophic Lateral Sclerosis Research Genetic Neurodegenerative Diseases Nerve injury and regeneration

Publication details

Journal / source
Lab on a Chip
Volume
26
Issue
5
Pages
1108–1122
Publication date
1 January 2026
Language
EN