A wearable 3D-printed hollow microneedle device for pressure-driven interstitial fluid collection and testing
Abstract
experiments on mice skin confirmed ISF extraction of up to 6 μL per sampling, with protein concentrations consistent with physiological levels. Collectively, this work presents a unified strategy for the design, fabrication, and evaluation of 3D-printed hollow MN systems with an integrated negative-pressure approach for ISF-based biomolecule analysis. In the future, further optimization and clinical validation of this platform would enable continuous, minimally invasive monitoring of a wide range of biomarkers, paving the way for point-of-care diagnostic and personalized health applications.
Fields of Study & Subjects
Advancements in Transdermal Drug Delivery
3D Printing in Biomedical Research
Microbial Inactivation Methods
Publication details
- Journal / source
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 26
- Issue
- 6
- Pages
- 1943–1957
- Publication date
- 1 January 2026
- Language
- EN