A smart 3D microfluidic tumor spheroid-vessel co-culture model for studying exosomal HSP-mediated tumor invasion and angiogenesis

Lab on a Chip 2026 Open access

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Authors: Sisi Zhou, Fanshu Shan, Yue Zhang, Yu Cao, Junhui Cen, Noritada Kaji, Songqin Liu
DOI: 10.1039/d5lc00857c
Cited by: 2
References: 47

Abstract

) reversed these effects, confirming that exosomal HSPs serve as critical mediators of tumor invasion and angiogenesis. This microfluidic model provides a physiologically relevant tool for studying metastatic mechanisms and screening therapeutic targets, highlighting exosomal HSPs as a promising intervention point.

Fields of Study & Subjects

3D Printing in Biomedical Research Extracellular vesicles in disease Cancer Cells and Metastasis

Publication details

Journal / source
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Volume
26
Issue
6
Pages
1820–1829
Publication date
1 January 2026
Language
EN