High-throughput biomimetic cycling of red blood cells: elucidating the morpho-mechanical determinants of fatigue and clearance
Abstract
the channel dimensions. Furthermore, simulations of splenic filtration identify the sphericity index-not membrane stiffness-as the primary geometric factor governing RBC retention in IES. This work presents a high-throughput, label-free platform that disentangles RBC fatigue induction from post-fatigue analysis. It provides mechanistic insights into how repetitive mechanical stress regulates RBC aging and clearance, offering a valuable tool for advancing our understanding of RBC physiology in health and disease.
Fields of Study & Subjects
Erythrocyte Function and Pathophysiology
Blood properties and coagulation
Hemoglobin structure and function
Publication details
- Journal / source
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 26
- Issue
- 3
- Pages
- 551–563
- Publication date
- 1 January 2026
- Language
- EN